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Gibco™ Human EGF, Animal-Free Recombinant Protein, PeproTech®

E. coli Recombinant Protein

83.25 € - 239.00 €

Specifications

Accession Number P01133
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 1950
Molecular Weight (g/mol) 6.2
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Products 3
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
17833373
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Gibco™
AF-100-15-100UG
100 μg
83.25 €
100µg
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17883153
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Gibco™
AF-100-15-1MG
1 mg
239.00 €
1mg
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17853743
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Gibco™
AF-100-15-500UG
500 μg
194.00 €
500µg
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Description

Description

EGF (Epidermal growth factor) exerts its actions by binding to the EGF Receptor, a 170 kDa protein kinase. Activation of EGFR initiates diverse cellular pathways in response to toxic environmental stimuli, or to EGF binding to the receptor, the EGFR forms homo- or heterodimers with other family members. Each dimeric receptor complex initiates a distinct signaling pathway by recruiting different Src homology 2 (SH2) containing effector proteins. EGF is far and wide expressed in kidney, cerebrum, prostrate and salivary glands. EGF acts as a potent mitogenic factor and the phosphorylated receptor recruits adapter proteins like GRB2 that activates complex downstream signaling cascades. EGF activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STAT modules. Research studies suggest the protein may also play important role in activating the NF-kappa-B signaling cascade. Defects in the EGGF gene are the cause of hypomagnesemia type 4 and dysregulation has been associated with the growth and progression of certain cancers.
Specifications

Specifications

P01133
protein with no preservative
6.2
E. coli
RUO
AI790464; beta-urogastrone; EGF; Epidermal growth factor; epidermal growth factor (beta-urogastrone); epidermal growth factor precursor; H-EGF; HOMG4; Pro-epidermal growth factor; Pro-epidermal growth factor precursor (EGF); sb:eu639; URG; Urogastrone
Human
Recombinant
Lyophilized
Functional Assay
1950
Human EGF, Animal-Free
-20°C
<0.1 EU/μg
EGF
Unconjugated
NSDSECPLSH DGYCLHDGVC MYIEALDKYA CNCVVGYIGE RCQYRDLKWW ELR
≥ 98% by SDS-PAGE gel and HPLC analyses.
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