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  4. Invitrogen™ Human ErbB2 Fc Chimera Recombinant Protein

Invitrogen™ Human ErbB2 Fc Chimera Recombinant Protein

Product Code. 17114173
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Quantity:
5 μg
50 μg
Unit Size:
50µg
5µg
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Product Code. 17114173

Brand: Invitrogen™ A42494

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Description

Recombinant Protein

Reconstitution: Dissolve the protein in sterile double distilled water to a concentration of 0.2 mg/mL or lower. It is recommended that the protein be aliquoted and be used as soon as possible. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles.

ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P04626
For Use With (Application) Control, Binding Assay, Bioactivity, Western Blot
Formulation PBS with 5% mannitol, 5% trehalose, 0.01% Tween 80 and no preservative; pH 7.4
Gene ID (Entrez) 2064
Molecular Weight (g/mol) 96.1 kDa
Name Human ErbB2 Fc Chimera
pH Range 7.4
Purification Method Purified
Quantity 50 μg
Source HEK293 cells
Storage Requirements -20°C or -80°C if preferred
Regulatory Status RUO
Endotoxin Concentration <1.0 EU/μg
Gene Alias avian erythroblastosis oncogene B 2; Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog); CD antigen CD340; CD340; c-erb B2/neu protein; c-erbB2; C-erbB-2; c-neu; epidermal growth factor receptor-related protein; erbb 2; ERBB2; erb-b2; Erbb-2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; erb-b2 receptor tyrosine kinase 2; her 2; HER2; HER-2; HER-2/neu; herstatin; human epidermal growth factor receptor 2; Kiaa3023; metas; Metastatic lymph node gene 19 protein; mKIAA3023; MLN 19; MLN19; NEU; Neu oncogene; NEU proto-oncogene; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; NGL; p185erbB2; p185neu; phospho ErbB2; proto-oncogene c-ErbB-2; Proto-oncogene Neu; receptor tyrosine-protein kinase erbB-2; TKR1; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Common Name Her-2 (ErbB2)
Gene Symbol ERBB2
KinaseFamily EGF Receptor (ErbB) Kinase Family
Biological Activity 1. Immobilized Human ErbB2 Fc Chimera Recombinant Protein (at 2 μg/mL (100 μL/well) can bind Anti-Erbb2 Antibody (Trastuzumab), the EC50 is 16-80 ng/mL 2. Measured by its ability to block anti-ErbB2 mediated inhibition of BT474 human breast ductal carcinoma cell proliferation. The ED50 for this effect is 0.5-3 μg/mL in the presence of 0.6 μg/mL Anti-ErbB2/Her2 Monoclonal Antibody.)
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag Fc-tag
Sequence Human ErbB2, amino acids Met1-Thr652 (Accession # NP_004439.2) with a C-terminal Fc-tag
Content And Storage Includes 1 vial of lyophilized protein. Store at -20 °C.
Activity 1. Immobilized Human ErbB2 Fc Chimera Recombinant Protein at 2 μg/mL (100 μL/well) can bind Anti-Erbb2 Antibody (Trastuzumab), the EC50 is 16-80 ng/mL.<br><br>2. Measured by its ability to block anti-ErbB2 mediated inhibition of BT474 human breast ductal carcinoma cell proliferation. The ED50 for this effect is 0.5-3 μg/mL in the presence of 0.6 μg/mL Anti-ErbB2/Her2 Monoclonal Antibody.
Endotoxin Level < 1 EU/μg
Kinase Group Tyrosine Kinases
Expression System HEK293 cells
Protein Family Growth Factors & Receptors
Protein Form Cell Surface Protein, Recombinant, Truncated
Form Lyophilized
Protein Subtype Growth Factor Receptors, Receptor Tyrosine Kinases
Research Category Cardiovascular Research, Immunology, Oncology, Signal Transduction, Stem Cell Research
Purity or Quality Grade ≥90 % as determined by SDS-PAGE. ≥90 % as determined by SEC-HPLC.
Protein v-erb-b2 erythroblastic leukemia viral oncogene homolog 2
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