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Gibco™ Human IFN-beta Recombinant Protein, PeproTech®

Product Code. 17841783
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Quantity:
100 μg
2 x 500 μg
20 μg
250 μg
5 μg
50 μg
500 μg
Unit Size:
100µg
1mg
20µg
250µg
500µg
50µg
5µg
Product Code. Quantity unitSize
17841783 20 μg 20µg
17801293 100 μg 100µg
17851783 2 x 500 μg 1mg
17820423 250 μg 250µg
17821073 500 μg 500µg
17881583 50 μg 50µg
17891783 5 μg 5µg
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Product Code. 17841783

Brand: Gibco™ 30002BC20UG

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Description

Recombinant Protein

300-02BC-1MG will be provided as 2 x 500 μg (300-02BC-500UG). PeproTech's Recombinant Human IFN-beta is a 20.0 kDa protein containing 166 amino acid residues. Due to glycosylation, IFN-beta has an approximate MW of 22.3 kDa based on SDS-PAGE gel and Mass Spectrometry. *Human IFN-beta (Catalog Number 300-02BC) has replaced Human IFN-beta (Catalog Number 300-02B) This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P01574
For Use With (Application) Control, Bioactivity
Formulation Protein with no preservative
Gene ID (Entrez) 3456
Molecular Weight (g/mol) 20 kDa
Name Human IFN-beta
Purification Method Purified
Quantity 20 μg
Source CHO cells
Storage Requirements -20°C
Regulatory Status RUO
Endotoxin Concentration <1 EU/μg
Gene Alias Fibroblast interferon; Ifb; IFF; IFN b; IFN β; IFNB; Ifnb1; IFNbeta; IFN-beta; IFNβ; Interferon; Interferon b; Interferon beta; interferon beta 1; interferon beta 1, fibroblast; interferon beta protein; interferon, beta 1; interferon, beta 1, fibroblast; interferon-beta; RP11-113D19.1
Common Name IFN beta
Gene Symbol Ifnb1
Biological Activity Determined by a cytotoxicity assay using human TF-1 cells. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10^7 units/mg
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Sequence MSYNLLGFLQ RSSNFQCQKL LWQLNGRLEY CLKDRMNFDI PEEIKQLQQF QKEDAALTIY EMLQNIFAIF RQDSSSTGWN ETIVENLLAN VYHQINHLKT VLEEKLEKED FTRGKLMSSL HLKRYYGRIL HYLKAKEYSH CAWTIVRVEI LRNFYFINRL TGYLRN
Content And Storage -20°C
Activity Determined by a cytotoxicity assay using human TF-1 cells. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10^7 units/mg.
Expression System CHO cells
Form Lyophilized
Purity or Quality Grade ≥ 95% by SDS-PAGE gel and HPLC analyses.
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