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Gibco™ Human IL-27 Recombinant Protein, PeproTech®
HEK293 cells Recombinant Protein
80.00 € - 5140.00 €
Specifications
Accession Number | Q14213, Q8NEV9 |
---|---|
For Use With (Application) | Functional Assay |
Formulation | protein with no preservative |
Gene ID (Entrez) | 10148, 246778 |
Molecular Weight (g/mol) | 47.8 |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17820643
|
Gibco™
200-38-100UG |
100 μg |
1030.00 €
100µg |
Estimated Shipment: 21-05-2024 Log in to see stock. |
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17810643
|
Gibco™
200-38-10UG |
10 μg |
194.00 €
10µg |
Estimated Shipment: 21-05-2024 Log in to see stock. |
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17821213
|
Gibco™
200-38-1MG |
1 mg |
5140.00 €
1mg |
Estimated Shipment: 21-05-2024 Log in to see stock. |
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17830083
|
Gibco™
200-38-250UG |
250 μg |
1802.00 €
250µg |
Estimated Shipment: 21-05-2024 Log in to see stock. |
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17831613
|
Gibco™
200-38-2UG |
2 μg |
80.00 €
2µg |
Estimated Shipment: 21-05-2024 Log in to see stock. |
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17890913
|
Gibco™
200-38-500UG |
500 μg |
3085.00 €
500µg |
Estimated Shipment: 21-05-2024 Log in to see stock. |
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17850063
|
Gibco™
200-38-50UG |
50 μg |
620.00 €
50µg |
Estimated Shipment: 21-05-2024 Log in to see stock. |
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Description
IL-27 (Interleukin 27) is a cytokine belonging to the IL-12 family, and is a heterodimeric cytokine composed of EBI3 and p28 subunits. IL-27 is produced by activated dendritic cells and macrophages in response to Toll-like receptor ligands and pro-inflammatory cytokines. IL-27 promotes CD4+ T cell differentiation to the Th1 lineage by inducing expression of the transcription factor T-bet and up regulating IL-12R beta2, which in turn suppresses Th2 and Th17 differentiation and proliferation. IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. IL-27 acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting IL-27 involvement in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet. In humans, the gene is located on the p arm of chromosome 16.Specifications
Q14213, Q8NEV9 | |
protein with no preservative | |
47.8 | |
HEK293 cells | |
RUO | |
cytokine receptor; EBI3; EBI-3; EBV-induced gene 3 protein; Epstein-Barr virus induced 3; Epstein-Barr virus induced gene 3; Epstein-Barr virus induced gene 3 (similar to Interleukin-27 beta chain precursor); epstein-Barr virus-induced gene 3 protein; Epstein-Barr virus-induced gene 3 protein homolog; Il27; IL-27; IL27 p28; IL-27 p28 subunit; IL27 subunit; IL-27 subunit alpha; IL-27 subunit beta; Il27a; IL-27 A; IL-27-A; IL27-A; Il27b; IL-27 B; IL27p28; IL-27p28; Il30; IL35 subunit; ILN; Interleukin; interleukin 27; interleukin 30; interleukin-27 subunit alpha; Interleukin-27 subunit beta; interleukin-30; MGC71873; M-IL-27 (p28); p28; RGD1561420 | |
Human | |
Recombinant | |
Lyophilized |
Functional Assay | |
10148, 246778 | |
Human IL-27 | |
-20°C | |
<1 EU/μg | |
Ebi3, IL27 | |
Unconjugated | |
p28 subunit: FPRPPGRPQL SLQELRREFT VSLHLARKLL SEVRGQAHRF AESHLPGVNL YLLPLGEQLP DVSLTFQAWR RLSDPERLCF ISTTLQPFHA LLGGLGTQGR WTNMERMQLW AMRLDLRDLQ RHLRFQVLAA GFNLPEEEEE EEEEEEEERK GLLPGALGSA LQGPAQVSWP QLLSTYRLLH SLELVLSRAV RELLLLSKAG HSVWPLGFPT LSPQP EBI3 subunit: RKGPPAALTL PRVQCRASRY PIAVDCSWTL PPAPNSTSPV SFIATYRLGM AARGHSWPCL QQTPTSTSCT ITDVQLFSMA PYVLNVTAVH PWGSSSSFVP FITEHIIKPD PPEGVRLSPL AERQLQVQWE PPGSWPFPEI FSLKYWIRYK RQGAARFHRV GPIEATSFIL RAVRPRARYY VQVAAQDLTD YGELSDWSLP ATATMSLGK | |
≥ 90% by SDS-PAGE gel and HPLC analyses. |