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Invitrogen™ Human LAG-3 (CD223) Fc Chimera Recombinant Protein

Product Code. 17986261
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17986261 500 μg 500µg
17965861 50 μg 50µg
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Product Code. 17986261 Supplier Invitrogen™ Supplier No. RP88096
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    1406.00 €
    1251.34 € / 500µg
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Estimated Shipment: 15-12-2026
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Description

Recombinant Protein

It is recommended that the protein be aliquoted for optimal storage. It is recommended that sterile water (330 μL) be added to the vial to prepare a stock solution of 0.15 mg/mL. Concentration is measured by UV.

LAG-3 is a 70-kDa surface glycoprotein in the immunoglobulin superfamily, with structural homology to CD4. It binds to MHC class II molecules with higher affinity than CD4 and is involved in the negative regulation of T cell activation and homeostatic proliferation. LAG-3 is expressed on the surface of activated T cells, including regulatory T cells, and NK cells. Notably, CD8+ T cells express LAG-3 at significantly higher levels than CD4+ T cells. Additionally, the coexpression of LAG-3 and CD49b has been proposed as a marker for identifying Type 1 regulatory T cells (Tr1 cells) in both humans and mice. This highlights LAG-3s role in immune regulation and its potential as a target for therapeutic interventions in immune-related conditions.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P18627
For Use With (Application) Binding Assay, Control, ELISA Standard
Format Lyophilized
Formulation PBS with 15% trehalose and no preservative; pH 7.4
Gene ID (Entrez) 3902
Molecular Weight (g/mol) 72.58 kDa
Name Human LAG-3 (CD223) Fc Chimera
pH Range 7.4
Purification Method Purified
Quantity 500 μg
Storage Requirements -20°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Endotoxin Concentration <1.0 EU/μg
Gene Alias Activation-induced cytidine deaminase-linked autoimmunity protein; Aida; CD223; FDC; LAG3; LAG-3; Ly66; lymphocyte activating 3; lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; Secreted lymphocyte activation gene 3 protein; sLAG 3; sLAG3; sLAG-3; soluble LAG 3lymphocyte activating 3; soluble LAG3
Common Name LAG-3 (CD223)
Gene Symbol LAG3
Biological Activity Immobilized LAG3 Protein, Human, Recombinant (ECD, mFc Tag) (at 2 μg/mL (100 μL/well) can bind Anti-LAG3 (BMS)-IgG4 Antibody (Relatlimab), the EC50 is 8-40 ng/mL)
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Protein Tag Fc-tag
Sequence Human LAG3, amino acids Met1-Leu450 (Accession # NP_002277.4) with a C-terminal mouse IgG1 Fc region
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Activity Immobilized LAG3 Protein, Human, Recombinant (ECD, mFc Tag) at 2 μg/mL (100 μL/well) can bind Anti-LAG3 (BMS)-IgG4 Antibody (Relatlimab), the EC50 is 8-40 ng/mL.
Expression System HEK293 cells
Form Lyophilized
Purity or Quality Grade ≥90% as determined by SDS-PAGE.
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