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Gibco™ Human OATP1B3 (G) SLC Transporter Cells

Product Code. 17116632
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Quantity:
8–10M cells
Unit Size:
Each
Product Code. Quantity unitSize
17116632 8–10M cells Each
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This item is not returnable. View return policy

Product Code. 17116632

Brand: Gibco™ GM1106G

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Beschreibung

HEK293 cells that transiently overexpress the OATP1B3 solute carrier (SLC) transport protein

  • TRANSiPORT Human OATP1B3 (G) SLC Transporter Cells are HEK293 cells that transiently overexpress the OATP1B3 solute carrier (SLC) transport protein. Solute carriers are a super-family of membrane transporters that can affect pharmacokinetics and drug exposure by governing the transport of solutes in and out of cells. The OATP1B3 SLC transporter protein is found in sinusoidal hepatocytes.
  • Assess potential for transporter-mediated drug metabolism
  • Easy to use format
  • Obtain high quality results with a large signal-to-noise ratio
  • Cell-based assays can be performed using radioisotope-labeled compounds, fluorescence-labeled compounds, or non-labeled compounds. The amount of substrate transported into the cells can be measured directly using a liquid scintillation counter, fluorescence plate reader, or LC-MS/MS, thereby allowing direct evaluation of SLC transporter activity.
  • Mock HEK293 cells (Cat. No. GM1101G) that do not overexpress the SLC transporter are available for use as a negative experimental control. Some compounds may demonstrate high background levels of transport due to the presence of endogenous transporters or non-specific binding.
  • The convenient product format enables data generation in 2 days from thawing of the cells to final results.
TRUSTED_SUSTAINABILITY

Spezifikation

Content And Storage Store in liquid nitrogen vapor phase.
Cell Line 293 (HEK)
Culture Type Mammalian Cell Culture
Species Human
No. of Cells 8-10 x 106
Product Type SLC Transporter Cell
Quantity 8–10M cells
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