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ACROBiosystems Human R-Spondin 1 / RSPO1 Protein, His Tag

Product Code. 15817627
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1 mg
50 μg
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1mg
50µg
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15817627 50 μg 50µg
15807627 1 mg 1mg
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Product Code. 15817627 Supplier ACROBiosystems Supplier No. RS1H422150UG

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Description

R-spondin-1 is also known as Roof plate-specific Spondin 1 (RSPO1) and cysteinerich and single thrombospondin domain containing protein 3 (Cristin 3), which is a secreted protein which belongs to the R-Spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. All Rspondins regulate Wnt/β-catenin signaling, but have distinct expression patterns. Like other R-Spondins, R-Spondin-1 contains two adjacent cysteinerich furinlike domains (aa 34-135) with one potential N-glycosylation site, followed by a thrombospondin (TSP1) motif (aa 147-207) and a region rich in basic residues (aa 211-263). Only the furinlike domains are needed for β-catenin stabilization. A putative nuclear localization signal at the C-terminus may allow some expression in the nucleus.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.7 kDa. The protein migrates as 38-42 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Specifications

Accession Number NP_001033722.1
Molecular Weight (g/mol) 28.7 kDa
Quantity 50 μg
Source Human R-Spondin 1, His Tag (RS1-H4221) is expressed from human 293 cells (HEK293). It contains AA Ser 21 - Ala 263 (Accession # Q2MKA7-1).
Immunogen Ser 21 - Ala 263
Storage Requirements -20°C
Gene Alias RSPO1,CRISTIN3,FLJ40906,RP11-566C13.1,R-spondin-1
Common Name R-Spondin 1
Conjugate Unconjugated
Species Human
Protein Tag His Tag
Buffer PBS, pH7.4
Endotoxin Level Less than 1.0 EU / μg by the LAL method.
Expression System HEK293
Form Powder
Protein Subtype Bio-Markers and CD Antigens
Purity or Quality Grade >95% as determined by SDS-PAGE
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