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  4. ACROBiosystems Human Siglec-2 / CD22 Protein, Llama IgG2b Fc Tag, low endotoxin

ACROBiosystems Human Siglec-2 / CD22 Protein, Llama IgG2b Fc Tag, low endotoxin

Product Code. 16498049
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Quantity:
1 mg
100 μg
Unit Size:
100µg
1mg

Product Code. 16498049

Brand: ACROBiosystems SI2H525a1mg

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Description

low endotoxin

B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2 / CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

This protein carries a llama IgG2b Fc tag at the C-terminus. The protein has a calculated MW of 103.0 kDa. The protein migrates as 120-140 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Specifications

Accession Number NP_001762.2
Molecular Weight (g/mol) 103.0 kDa
Quantity 1 mg
Source Human Siglec-2, Llama IgG2b Fc Tag, low endotoxin (SI2-H525a) is expressed from human 293 cells (HEK293). It contains AA Asp 20 - Arg 687 (Accession # P20273-1).
Immunogen Asp 20 - Arg 687
Storage Requirements -20°C
Gene Alias CD22,SIGLEC2,BL-CAM,SIGLEC-2,Siglec2,SIGLEC2FLJ22814
Common Name Siglec-2
Conjugate Unconjugated
Species Human
Protein Tag Llama IgG Fc Tag
Buffer Tris with Glycine, Arginine and NaCl, pH7.5
Endotoxin Level Less than 0.01 EU / μg by the LAL method.
Expression System HEK293
Form Powder
Protein Subtype Bio-Markers and CD Antigens
Purity or Quality Grade >95% as determined by SDS-PAGE
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