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Invitrogen™ Human SLC9A7 (aa 639-691) Control Fragment Recombinant Protein

Product Code. 30201476
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. 30201476

Brand: Invitrogen™ RP100443

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Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (92%), Rat (92%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-61843 (PA5-61843. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

Na+/H+ exchangers (NHE) of mammalian cells are plasma membrane intrinsic proteins mediating exchange of N+ and H+ ions in various tissues. The NHE catalyzes the electroneural transport of extracellular Na+ for intracellular H+. They play a major role in regulation of intracellular pH (pHi) in addition to trans-cellular absorption of Na+, cell volume regulation and possibly in cell proliferation. These primary functions of the Na+/H+ exchanger have been related to many pathophysiological states, include hypertension, organ growth and hypertrophy, regression of cancer and renal intestinal disorders. At least 7 NHE isoforms (NHE1-7) have been cloned so far. They are all similar in their primary structure and predicted to have 10-12 transmembrane domains. The C-terminal domain of NHEs are predicted to be intracellular. NHE7 (human 725 aa, chromosome Xp11.4) is ubiquitously expressed, and predominantly localizes to the trans-golgi network. NHE7 mediates the influx of Na+ or K+ in exchange for H+. It is ∽70% related to NHE6 but relatively less (∽25%) homologous with other NHEs.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q96T83
Concentration ≥5.0 mg/mL
For Use With (Application) Blocking Assay, Control
Formulation 1 M urea, PBS with no preservative; pH 7.4
Gene ID (Entrez) 84679
Name Human SLC9A7 (aa 639-691) Control Fragment
Quantity 100 μL
Regulatory Status RUO
Gene Alias A530087D17Rik; hypothetical protein LOC554532; Na(+)/H(+) exchanger 7; Nhe7; NHE-7; nonselective sodium potassium/proton exchanger; SLC9A6; Slc9a7; Sodium/hydrogen exchanger 7; solute carrier family 9 (sodium/hydrogen exchanger), isoform 7; solute carrier family 9 (sodium/hydrogen exchanger), member 7; solute carrier family 9 member 7; solute carrier family 9 member A7; solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7; wu:fk03b09; zgc:101088; zgc:113878
Common Name SLC9A7
Gene Symbol SLC9A7
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence QVYDNQEPLREEDSDFILTEGDLTLTYGDSTVTANGSSSSHTASTSLEGSRRT
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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