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Gibco™ Human TWEAK Receptor Recombinant Protein, PeproTech®

Product Code. p-7246069
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Quantity:
1 mg
100 μg
25 μg
250 μg
5 μg
500 μg
Unit Size:
100µg
1mg
250µg
25µg
500µg
5µg
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Product Code. 17892863

Brand: Gibco™ 31021100UG

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Description

Recombinant Protein

Recombinant Human soluble TWEAKR is a 53 amino acid polypeptide (5.6 kDa) comprising the entire extracellular domain of the full-length TWEAKR protein. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

TWEAK is a member of the TNF family and was first described as a weak inducer of apoptosis in demonstrate that this relatively small molecule is a fully transformed cell lines. Recently, a receptor for TWEAK was isolated by expression cloning from a HUVEC cell cDNA library. TweakR is a small protein belonging to TNF receptor super family. TweakR is capable of intiating a proliferative signal by binding to TRAF1, 2, and 3. TweakR mRNA is upregulated during tissue regeneration in the aorta and liver. It may also play a role in vascular cell migration and angiogenesis.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q9NP84
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 51330
Molecular Weight (g/mol) 5.6 kDa
Name Human TWEAK Receptor
Quantity 100 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias AI255180; C87282; CD266; FGF-inducible 14; Fgfrp2; fibroblast growth factor regulated protein 2; fibroblast growth factor-inducible immediate-early response protein 14; Fibroblast growth factor-regulated protein 2; FN14; HPIP; TNF receptor superfamily member 12 A; TNFRSF12A; Tumor necrosis factor receptor superfamily member 12 A; tumor necrosis factor receptor superfamily, member 12 A; TweakR; TWEAK-R; Tweak-receptor; type I transmembrane protein Fn14
Common Name CD266
Gene Symbol TNFRSF12A
Biological Activity Determined by its ability to inhibit TWEAK-induced weak cell death of HT29 cells. The expected ED50 for this effect is 1.0-3.0 ug/ml
Conjugate Unconjugated
Recombinant Recombinant
Sequence EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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