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Invitrogen™ Human VEGFR3 (Flt-4) His-tag Recombinant Protein
Recombinant Protein
Brand: Invitrogen™ RP88181
268.14 EUR valid until 2024-06-28
Use promo code "21649" to get your promotional price.
Additional Details : Weight : 0.01000kg
Description
Vascular endothelial growth factor is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specificl ymphatic endothelial receptor VEGFR-3. In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR3 has an essential role in the development of theembryonic cardiovascular system before the emergence of the lymphatic vessels.Specifications
| P35916 | |
| Lyophilized | |
| 2324 | |
| FLT4 | |
| 100 μg | |
| RUO | |
| AI323512; Chy; chylous ascites; Flt4; FLT-4; FLT41; fms related tyrosine kinase 4; FMS-like tyrosine kinase 4; fms-related tyrosine kinase 4; LMPH1A; PCL; receptor protein tyrosine kinase; soluble VEGFR 3; sVEGFR 3; tyrosine-protein kinase receptor FLT4; Vascular endothelial growth factor receptor 3; vascular endothelial growth factor receptor-3; VEGF R3; VEGFR3; VEGFR-3 | |
| Protein | |
| Unconjugated | |
| Human VEGFR3, amino acids Met1-Ile776 (Accession # NP_002011.2) with a C-terminal His-tag | |
| HEK293 cells |
| ELISA | |
| PBS with 0.01% Tween 80, 5% mannitol, 5% trehalose and no preservative; pH 7.4 | |
| 130 kDa | |
| SDS-PAGE | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| <1.0 EU/ μg | |
| FLT4 | |
| Human | |
| Recombinant | |
| 1. Measured by its binding ability in a functional ELISA. 2. Immobilized human VEGF-C (at 10 μg/mL (100 μL/well) can bind human VEGFR3-his. The EC50 of human VEGFR3-his is 0.011 μg/mL) | |
| >97% as determined by SDS-PAGE. |