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Tocris Bioscience™ IN 1130
Potent and selective inhibitor of TGF-βRI
Brand: Tocris Bioscience™ 6016/5
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Description
IN 1130 is a potent and selective inhibitor of TGF-β type I receptor (ALK5). Inhibits Smad-2 phosphorylation (IC50 = 5.3 nM). Exhibits selectivity over a panel of 27 serine/ threonine and tyrosine kinases including P38α. Attenuates TGFβ/Smad signaling, cell migration, invasion, lung metastasis and increases survival of mice in 4TI in vivo models. Suppresses renal fibrosis in obstructive nephropathy in vivo models.Specifications
| 3-[[5-(6-Methyl-2-pyridinyl)-4-(6-quinoxalinyl)-1H-imidazol-2-yl]methyl]benzamide | |
| 868612-83-3 | |
| >98% | |
| 5 mg |
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