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Tocris Bioscience™ Itraconazole
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Product Code. 18745836
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50 mg
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Product Code. 18745836 Supplier Tocris Bioscience™ Supplier No. 5981/50

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86.70 EUR valid until 2026-03-31
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Description

SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)

Itraconazole is a SMO antagonist (IC50 = 690 nM); acts at different binding site to cyclopamine (Cat. No. 1623). Also cytochrome p450 inhibitor (IC50 = 16-26 nM). Inhibits cell cycle at G1 phase in vitro and blocks angiogenesis in vivo (IC50 = 160 nM). Antifungal.
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Specifications

Chemical Name or Material 4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one
CAS 84625-61-6
Quantity 50 mg
Target Smoothened Receptor Antagonists
Molecular Formula C35H38Cl2N8O4
Formula Weight 705.63
Purity >99%
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