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STEMCELL Technologies IWP-2

Product Code. 17190022
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Product Code. 17190022 Supplier STEMCELL Technologies Supplier No. 72122

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Description

WNT pathway inhibitor; Inhibits Porcupine

  • IWP-2 inhibits the WNT pathway (IC50 = 27 nM) at the level of the pathway activator Porcupine
  • Porcupine is a membrane-bound acyltransferase that palmitoylates WNT proteins, which leads to WNT secretion and signaling capability
  • (Chen et al.), Willert et al.)
  • Suppresses self-renewal of mouse embryonic stem (ES) cells and supports their conversion to epiblast-like stem cells (ten Berge et al.)
  • Inhibits maintenance and proliferation of mouse Lgr5+ intestinal and cochlear epithelial stem cells, demonstrating the importance of WNT signaling in these processes (Chai et al.), Farin et al.)
  • Promotes cardiomyocyte differentiation from human pluripotent stem cells (Lian et al.), Minami et al.)

Specifications

CAS 686770-61-6
Synonym Inhibitor of WNT Production-2
Quantity 1 mg
Molecular Formula C22H18N4O2S3
Purity ≥95%
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