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Tocris Bioscience™ IWP 2
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Product Code. 18083912
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18083912 10 mg 10mg
18035402 50 mg 50mg
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Product Code. 18083912 Supplier Tocris Bioscience™ Supplier No. 3533/10

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271.70 EUR valid until 2026-02-13
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Description

PORCN inhibitor; inhibits Wnt processing and secretion

IWP 2 is a potent inhibitor of Wnt processing and secretion (IC50 = 27nM). IWP 2 inactivates PORCN, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. Blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and β-catenin accumulation. IWP 2 suppresses self-renewal in R1 embryonic stem cells and promotes cardiomyocyte differentiation from hPSCs.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 686770-61-6
Molecular Formula C22H18N4O2S3

Specifications

Quantity 10 mg
Formula Weight 466.6
Purity >98%
Molecular Weight (g/mol) 466.59
Chemical Name or Material IWP 2
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