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STEMCELL Technologies IWR-1-endo

Product Code. 17110092
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Quantity:
5 mg
25 mg
Unit Size:
25mg
5mg
Product Code. Quantity unitSize
17110092 25 mg 25mg
17100092 5 mg 5mg
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Product Code. 17110092

Brand: STEMCELL Technologies undefined

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Description

WNT pathway inhibitor; AXIN2 stabilizer

  • IWR-1-endo potently inhibits WNT signaling by blocking a cell-based WNT/β-catenin pathway reporter response with an IC50 value of 180 nM (Chen et al.) It inhibits WNT-induced accumulation of β-catenin, through stabilization of the destruction complex member AXIN2 (Chen et al.)
  • Promotes self-renewal and maintains pluripotency of human embryonic stem cells and mouse Epi-stem cells when used in combination with CHIR99021 (Kim et al.) DIFFERENTIATION
  • Promotes differentiation of cardiomyocytes from human pluripotent stem cells (PSCs) that have been induced to mesoderm by addition of Activin A and/or BMP4 (Ren et al.; Willems et al.)
  • Induces the differentiation of human PSC-derived alveolar epithelial type II (AETII) to AETI cells (Ghaedi et al.)

Specifications

CAS 1127442-82-3
Quantity 25 mg
Molecular Formula C25H19N3O3
Purity ≥98%
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