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  4. Invitrogen™ Human JAK2, GST Tag Recombinant Protein

Invitrogen™ Human JAK2, GST Tag Recombinant Protein

Product Code. 11503637
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Quantity:
10 μg
100 μg
Unit Size:
100µg
10µg
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Product Code. 11503637

Brand: Invitrogen™ PV4210

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This item is not returnable. View return policy

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Recombinant, Catalytic Domain, Cytoplasmic.

Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Mutations affecting JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number O60674
Concentration See Label
For Use With (Application) Kinase Assay
Formulation 50mM tris with 0.5mM EDTA, 50% glycerol, 0.02% Triton X-100, 2mM DTT, 150mM NaCl and no preservative; pH 7.5
Gene ID (Entrez) 3717
Molecular Weight (g/mol) 66.6 kDa
Name Human JAK2, GST Tag
pH Range 7.5
Purification Method Purified
Quantity 10 μg
Storage Requirements -80°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Gene Alias EC 2.7.10.2; Fd17; JAK 2; JAK2; JAK-2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK 10; JTK10; kinase Jak2; THCYT3; Tyrosine-protein kinase JAK2
Common Name JAK2
Gene Symbol JAK2
KinaseFamily JAK Kinase Family
Protein Length 809-1153 +9
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag GST-tag
Sequence 809-1153 +9
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Assay Entry Biochemical phospho-specific activity (no antibody), Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
Kinase Group Tyrosine Kinases
Shipping Condition Dry Ice
System Compatibility LanthaScreen™ Antibody, LanthaScreen™ Substrate, Z'-LYTE™, Omnia™ Bulk Substrate
Target Entry JAK2
Target Gene Janus kinase 2
Expression System Insect cells
Protein Family Kinases & Inhibitors
Protein Form Recombinant, Catalytic Domain, Cytoplasmic
Form Liquid
Protein Subtype Cytoplasmic Tyrosine Kinases
Research Category Signal Transduction
Purity or Quality Grade 95% by SDS-PAGE
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