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Tocris Bioscience™ JW 74
Wnt pathway inhibitor
Brand: Tocris Bioscience™ 5653/50
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Description
JW 74 is an inhibitor of canonical Wnt signaling (IC50 = 790 nM). Targets the β-catenin destruction complex (GSK-3?/AXIN/APC). Increases AXIN2 and decreases active β-catenin levels in colorectal cancer (CRC) cells. Also arrests cell cycle in G1 and inhibits proliferation of CRC cells in vitro. Inhibits tumor growth and formation in mouse models.Specifications
| 4-[4-(4-Methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-pyridine | |
| 863405-60-1 | |
| 50 mg | |
| Soluble to 100mM in DMSO |
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