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STEMCELL Technologies Kenpaullone

Product Code. 17160122
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Quantity:
10 mg
Unit Size:
10mg
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Product Code. 17160122

Brand: STEMCELL Technologies 72782

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This item is not returnable. View return policy

Description

WNT pathway activator; Inhibits GSK3

  • Kenpaullone is an ATP-competitive inhibitor of glycogen synthase kinase 3β (GSK-3β; Bain et al.; Leclerc et al.; Zaharevitz et al.) It inhibits GSK-3β, Cdk1/cyclin B, Cdk2/cyclin A, Cdk5/p25, and lymphocyte kinase with IC50 values of 0.23, 0.4, 0.68, 0.85, and 0.47 μM, respectively (Bain et al.; Zaharevitz et al.)
  • Replaces Klf4 in the generation of induced pluripotent stem (iPS) cells from mouse embryonic fibroblasts (MEFs) transduced with Oct4, Sox2, and c-Myc (Lyssiotis et al.)
  • Enhances neuronal differentiation in rat and human neural precursor cell cultures (Castelo-Branco et al.; Lange et al.)
  • Promotes survival of motor neurons derived from mouse embryonic stem (ES) cells and from Amyotrophic Lateral Sclerosis (ALS) patient iPS cells (Yang et al.)
  • Inhibits KLF4 expression and self-renewal in breast cancer stem cells in vitro (Yu et al.)

Specifications

CAS 142273-20-9
Synonym 9-Bromopaullone; NSC 664704
Quantity 10 mg
Molecular Formula C16H11BrN2O
Purity ≥98%
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