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Tocris Bioscience™ Lonafarnib
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Product Code. 18799046
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18799046 50 mg 50mg
18748236 10 mg 10mg
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Product Code. 18799046 Supplier Tocris Bioscience™ Supplier No. 6265/50

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667.20 EUR valid until 2026-03-31
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Description

Potent farnesyl transferase inhibitor

Lonafarnib is a potent farnesyl transferase inhibitor (IC50 = 1.9 nM). Inhibits farnesylation of RAS. Also inhibits Pgp transport (IC50 < 3 μM) and increases potency and anticancer activity when used in conjunction with cytotoxic Pgp substrates. Inhibits neovascularization by affecting cell motility. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide
CAS 193275-84-2
Assay Percent Range >98%
Quantity 50 mg
Molecular Formula C27H31Br2ClN4O2
Formula Weight Observed MW: 638.82
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