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Tocris Bioscience™ LSN 2463359
GREENER_CHOICE

Potent and selective positive allosteric modulator at mGlu5

Brand:  Tocris Bioscience™ 5275/50

Encompass

Product Code. 15756646

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Description

Description

LSN 2463359 is a potent and selective positive allosteric modulator at the mGlu5 receptor (EC50 = 24 nM). Has no activity at mGlu1-4, mGlu8 and GABAB receptors. Reverses methylazoxymethanol acetate (MAM)-induced deficits in reversal learning memory and normalizes SDZ 220-581 and RO 63-1908 -induced alterations in instrumental responses in rat models. Promotes wakefulness in vivo. Brain penetrant and orally active.
Specifications

Specifications

>99%
50 mg
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