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Eurofins DiscoverX MSK1 Protein, Active

Product Code. 17360324
Encompass_Preferred
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Quantity:
10 μg
250 μg
Unit Size:
10µg
250µg
This item is not returnable. View return policy

Product Code. 17360324

Brand: Eurofins DiscoverX 14548

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This item is not returnable. View return policy

Description

Active, N-terminal His6-tagged recombinant human MSK1 residues 2-end, for use in Kinase Assays.

Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).

GenBank AF074393

Specifications

Formulation mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 50% glycerol, 150 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Liquid at -20°C.
Molecular Weight (g/mol) 94 kDa
Quantity 10 μg
Species Human
Recombinant Recombinant
Protein Tag N-terminal 6His
Expression System Recombinant enzyme expressed in Sf21 insect cells
Protein Form Truncated
Purity or Quality Grade ≥70%
Protein MSK1 (2-end), active
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