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Tocris BioScience™ NAIA

Product Code. 31900403
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Product Code. 31900403 Supplier Tocris BioScience™ Supplier No. 8910/5

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Description

Broad spectrum cysteine reactive probe; suitable for live-cell applications

NAIA (N-Acryloylindole-alkyne) is a broad-spectrum cysteine reactive probe enabling cysteine profiling and imaging. It covalently binds cysteine residues in proteins.

Displays faster reaction kinetics with CYS (k > 102 M-1 s-1) and targets an expanded pool of ligandable cysteines and proteins compared to IA-Alkyne (Cat. No. 7015). Also shows higher stability and selectivity for CYS over SER and LYS than IA-Alkyne (Cat. No. 7015).

NAIA is used in chemoproteomics experiments as a click-chemistry handle to attach a fluorophore or biotin to reactive cysteines in proteins for visualization by in-gel fluorescence or identification by mass spectrometry, respectively. NAIA can also be used to image oxidized cysteines in cells under oxidative stress by confocal fluorescence microscopy.

Cell-permeable and non-cytotoxic, NAIA is suitable for live-cell experiments.

TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material N-5-Hexyn-1-yl-2-[[1-(1-oxo-2-propen-1-yl)-1H-indol-5-yl]oxy]acetamide
CAS 3020685-33-7
Quantity 5 mg
Target Buffers, Chelators and Reagents
Molecular Formula C19H20N2O3
Purity 95%
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