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  5. Tocris Bioscience™ NI 57

Tocris Bioscience™ NI 57
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Product Code. 18700518
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18700518 10 mg 10mg
18744059 50 mg 50mg
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Product Code. 18700518 Supplier Tocris Bioscience™ Supplier No. 5546/10

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Description

Potent and selective BRPF bromodomain inhibitor

NI 57 is a potent and selective BRPF bromodomain inhibitor (Kd values are 31, 108 and 408 nM, for BRPF1B, 2 and 3, respectively, which exhibits >32-fold selectivity for BRPFs over BRD9 and other non-Class IV bromodomains. NI 57 inhibits RANKL-induced differentiation of primary murine bone marrow cells and human primary monocytes into osteoclasts.
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Specifications

Chemical Name or Material 4-Cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-methoxybenzene-1-sulfonamide
CAS 1883548-89-7
Quantity 10 mg
Target Bromodomain Inhibitors
Molecular Formula C19H17N3O4S
Formula Weight 383.42
Purity 98%
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