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STEMCELL Technologies Nocodazole

Product Code. 17140322
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Product Code. 17140322 Supplier STEMCELL Technologies Supplier No. 74074

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Description

Microtubule polymerization inhibitor; Inhibits beta-tubulin

  • Nocodazole is an anti-mitotic agent that reversibly interferes with the polymerization of microtubules (De Brabander et al.) Nocodazole binds to beta-tubulin and disrupts microtubule assembly/disassembly dynamics, impairing formation of the metaphase spindles during the cell division cycle
  • This prevents mitosis by inducing a G2/M-phase arrest and induces apoptosis in tumor cells (Jordan et al.)
  • Synchronizes human pluripotent stem cells (hPSCs) in the G2/M cell cycle phase, thereby increasing the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Lin et al.; Yang et al.)
  • Induces apoptosis in leukemic cells without harming T cells and/or mesenchymal stromal cells that were recovered from the same patients (Frezzato et al.)

Specifications

CAS 31430-18-9
Synonym NSC 238159; Oncodazole; R 17934
Quantity 50 mg
Molecular Formula C14H11N3O3S
Purity ≥98%
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