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Tocris Bioscience™ OICR 9429
High affinity and selective WDR5 antagonist
Brand: Tocris Bioscience™ 5267/50
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Description
OICR 9429 is a high affinity WDR5 antagonist (Kd = 93 nM; IC50 = 64 nM); disrupts WDR5-MLL interaction. Exhibits selectivity for WDR5 over 22 methyltransferases and a panel of kinases, GPCRs, ion channels, and transporters. Reduces viability of acute myeloid leukemia cells in vitro. Also disrupts MLL1-RbBP5 interaction.To request the negative control for OICR 9429, please fill out the OICR 0547 request form on the SGC website.
Specifications
| OICR 9429 | |
| 50 mg | |
| Solid |
| N-[2-(4-Methylpiperazin-1-yl)-5-[3-(morpholin-4-ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide | |
| Soluble to 50mM in DMSO | |
| Bioactive Small Molecule |
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