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Ion Torrent™ Oncomine™ Comprehensive Assay Plus GX DNA
Description
The Ion Torrent Oncomine Comprehensive Assay Plus GX DNA is a targeted next-generation sequencing (NGS) assay that provides a comprehensive genomic profiling (CGP) solution appropriate for formalin-fixed paraffin-embedded (FFPE) tissues from solid tumors. The assay detects a broad range of genomic alterations from 501 genes, including single-nucleotide variants (SNVs), insertions and deletions (indels), and copy number variations (CNVs) from DNA. Additionally, the assay detects genomic signatures such as homologous recombination deficiency (HRD) using genomic instability metric (GIM), tumor mutational burden (TMB), and microsatellite instability (MSI). This assay is the DNA component of the Oncomine Comprehensive Assay Plus GX (Cat. No. A47013), which includes both DNA and RNA assays.
Key features of the assay include:
- Enables CGP across 501 genes
- Accurately detects SNVs, indels, and CNVs, including large genomic rearrangements (LGRs) in BRCA1 and BRCA2
- Assesses for genomic signatures, including HRD, TMB, and MSI, to help maximize insights on the underlying oncogenic drivers
- Provides robust performance from 30 ng of DNA from FFPE samples, including fine needle biopsies
- Provides multiplex sequencing of up to four DNA samples with optional NTC on a GX7 Chip in a single run
- System-installed assays preconfigured with settings optimized for specific applications and sample types
- Requires as little as 10 minutes hands-on time per run for easy, automated workflows
- Provides automated Nucleic Acid to Result workflow on the Genexus Integrated Sequencer with next-day results
When used with the Genexus Purification System and the Genexus Integrated Sequencer, sequential sample purification, library preparation, sequencing, and analysis allow for the reporting of next-day results. With just two user touchpoints and as little as 20 minutes of hands-on time, the easy, automated workflows can help reduce handling errors, free up time for your laboratory staff, and reduce labor costs. As a single vendor of sample-to-report solutions, including instruments, consumables, analysis, and support, Thermo Fisher Scientific simplifies bringing in-house CGP to your lab at varying levels of NGS expertise.
Spécification
Spécification
| Sample Type | DNA from FFPE |
| Sequencing Type | Next Generation Sequencing |
| For Use With (Equipment) | Genexus™ Integrated Sequencer |
| Product Type | Oncomine Comprehensive Assay Plus GX DNA |
| Quantity | 16 Samples |
For Research Use Only. Not for use in diagnostic procedures.
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