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Tocris Bioscience™ ONO AE3 208
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Product Code. 18754719
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18754719

Brand: Tocris Bioscience™ 3565/50

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Description

High affinity and selective EP4 antagonist

ONO AE3 208 is a high affinity and selective EP4 receptor antagonist (Ki values are 1.3, 30, 790 and 2400 nM for EP4, EP3, FP and TP receptors respectively). Displays no affinity for EP1, EP2, DP or IP receptors (Ki >10 μM). Inhibits PGE2-induced IL-8 production in colonic epithelial caco-2 cells and attenuates PGE2 inhibition of natural killer T cell activation. Suppresses recovery from experimentally-induced colitis and stimulates CD4+ T cell proliferation in C57BL/6 mice. Also reduces metastasis of mammary tumor cells in a murine model of breast cancer. Orally active.
TRUSTED_SUSTAINABILITY

Specifications

Quantity 50 mg
Product Type ONO AE3 208
Purity >98%
Molecular Weight (g/mol) 404.43
Inhibitors ONO AE3 208

For Research Use Only

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