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DiscoverX PathHunter™ eXpress CHRM4 Total GPCR Internalization Assay

Product Code. 17303989
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Quantity:
1,000 dp (10 x 96-well)
Unit Size:
1 set
Product Code. Quantity unitSize
17303989 1,000 dp (10 x 96-well) 1 set
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Product Code. 17303989

Brand: DiscoverX 930902E3CP0L

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This item is not returnable. View return policy

Description

The PathHunter™ eXpress CHRM4 Total GPCR Internalization Assay measures CHRM4 (GPCR) internalization via early-endosome localization. eXpress kits contain all assay materials: cells, reagents, and plates.

The PathHunter™ CHRM4 Total GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit assesses ligand (e.g. acetycholine) based internalization of CHRM4 via detection of localization to the early endosome. This product uses EFC technology. The included cells overexpress PK-tagged CHRM4 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the CHRM4 receptor to the early endosome leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Specifications

Assay Entry Total Internalization
For Use With (Application) Assay-Ready eXpress Kits
Primary Agonist Acetylcholine
Quantity 1,000 dp (10 x 96-well)
Target Entry CHRM4
Cell Line U2OS
Target CHRM4
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