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DiscoverX PathHunter™ Jurkat ICOS Signaling Assay

Product Code. 17384399
Encompass
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Quantity:
2 Vials
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17384399

Brand: DiscoverX 931127C19

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This item is not returnable. View return policy

Description

The PathHunter™ Jurkat ICOS Signaling Assay measures ICOS signal by recruitment of SH2 domain protein to the activated receptor. This cell line ships as two vials of cryopreserved cells.

The PathHunter ICOS Checkpoint Signaling cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting signaling checkpoints. This cell line enables assessment of ligand (e.g. ICOS-L) based activation of ICOS receptors via detection of SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged ICOS target protein and EA-tagged SH2 domain protein. Upon activation of the receptor by its ligand or an agonist antibody, recruitment of SH2 domain protein to the phosphorylated receptor tail leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Jurkat
Cell Line Jurkat
For Use With (Application) Cell Lines
Primary Agonist Anti-ICOS antibody
Quantity 2 Vials
Target Entry ICOS
Accession Number NM_012092.3
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