missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. 30245504

Tocris Bioscience™ PDEdelta ATTEC 12C

Product Code. 30245504
Click to view available options
:
5 mg
This item is not returnable. View return policy

Product Code. 30245504

Brand: Tocris Bioscience™ 8824/5

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

PDEδ autophagy-tethering compound (ATTEC) Degrader

PDEδ ATTEC 12C is a selective PDEδ autophagy-tethering compound (ATTEC) Degrader (DC50 = 1.7 μM; Dmax = 85%; Kd = 56 nM). Degrades PDEδ through lysosome-mediated autophagy. Inhibits proliferation of KRAS mutant Capan-1 and MiaPaCa-2 pancreatic cancer cells (IC50 values are 0.8 μM and 1.4 μM respectively); dose- and time-dependently induces apoptosis.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material N-(6-(2-(2,6-Dibromo-4-((5-iodo-2-oxoindolin-3-ylidene)methyl)phenoxy)acetamido)hexyl)-4-(3,4-dimethyl-7-oxo-2-(p-tolyl)-2,7-dihydro-6H-pyrazolo[3,4-d]pyridazin-6-yl)butanamide
Quantity 5 mg
Target Active Degraders
Molecular Formula C41H42Br2IN7O5
Purity 98%
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.