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Tocris Bioscience™ Picropodophyllotoxin

Description
Orally active insulin-like growth factor 1 receptor (IGF1R) inhibitor that exhibits no activity at the insulin receptor, FGFR, PDGFR or EGFR. Inhibits IGF1R autophosphorylation (IC50 ∽ 1 nM), increases the fraction of cells in the G2/M phase and upregulates apoptosis. Exhibits antiproliferative effects in multiple cancer cell lines (IC50 = 0.05 - 15 μM), and has anticancer and antineovascularization activity in vivo.
Specifications
Specifications
| CAS | 477-47-4 |
| Quantity | 10 mg |
| Molecular Formula | C22H22O8 |
| Formula Weight | 414.41 |
| Purity | >97% |
| Molecular Weight (g/mol) | 414.41 |
| Chemical Name or Material | Picropodophyllotoxin |
Product Title
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