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  5. Tocris Bioscience™ PKUMDL WQ 2101

Tocris Bioscience™ PKUMDL WQ 2101
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Product Code. 18758046
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25 mg
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18758046 25 mg 25mg
18729316 5 mg 5mg
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Product Code. 18758046 Supplier Tocris Bioscience™ Supplier No. 6580/25

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Description

Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)

PKUMDL WQ 2101 is a negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 34.8 μM). Exhibits antitumor activity in vitro in breast cancer cells lines overexpressing PHGDH (EC50 values are 7.7 and 10.8 μM in MDA-MB-468 and HCC-70 cells, respectively). Inhibits growth of MDA-MB-468 xenografts in mice.
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Specifications

Chemical Name or Material 2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide
CAS 304481-72-9
Quantity 25 mg
Molecular Formula C14H11N3O6
Formula Weight 317.25
Purity 98%
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