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  4. ACROBiosystems Rat ROR1 Protein, His Tag

ACROBiosystems Rat ROR1 Protein, His Tag

Product Code. p-7217072
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Quantity:
1 mg
100 μg
Unit Size:
100µg
1mg
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15827607 1 mg 1mg
15817607 100 μg 100µg
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Product Code. 15827607 Supplier ACROBiosystems Supplier No. RO1R52211MG

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Description

Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 43.5 kDa. The protein migrates as 60-67 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Specifications

Accession Number EDL97819
Molecular Weight (g/mol) 43.5 kDa
Quantity 1 mg
Source Rat ROR1, His Tag (RO1-R5221) is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Glu 403 (Accession # EDL97819).
Immunogen Gln 30 - Glu 403
Storage Requirements -20°C
Gene Alias ROR1,NTRKR1
Common Name ROR1
Conjugate Unconjugated
Species Rat
Protein Tag His Tag
Buffer PBS, pH7.4
Endotoxin Level Less than 1.0 EU / μg by the LAL method.
Expression System HEK293
Form Powder
Protein Subtype Bio-Markers and CD Antigens
Purity or Quality Grade >95% as determined by SDS-PAGE
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