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DiscoverX Ready-to-Assay™ IP1 Prostanoid Receptor Frozen Cells

Product Code. 17325259
Encompass
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Quantity:
2 Vials of Cells
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17325259

Brand: DiscoverX HTS131LRTA

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This item is not returnable. View return policy

Description

The Ready-to-Assay™ IP1 Prostanoid Receptor Frozen Cells measure PTGIR (GPCR) activation via an increase in intracellular calcium. Ready-to-Assay kits contain two vials of thaw-and-use cells.

The Ready-to-Assay™ IP1 Prostanoid Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. prostaglandin I2) based activation of PTGIR GPCR activity via detection of increasing levels of intracellular calcium. The included cells overexpress PTGIR alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of PTGIR , the resulting calcium activity can be assayed in either detection mode. Ready-to-assay kits consist of two vials of the cells in a convenient thaw-and-use format.

Specifications

Assay Entry IP1
For Use With (Application) Frozen Cells
Primary Agonist prostaglandin I2
Quantity 2 Vials of Cells
Target Entry PTGIR
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