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  5. Tocris Bioscience™ SEN 177

Tocris Bioscience™ SEN 177
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Product Code. p-7223021
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18758736

Brand: Tocris Bioscience™ 6979/10

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Description

Potent glutaminyl cyclase inhibitor; disrupts binding of SIRP-α to CD47

SEN 177 is a potent glutaminyl cyclase (QPCT) inhibitor (IC50 = 53 nM). SEN 177 reduces aggregation of mutant huntingtin (mHTT) through inhibition of QPCT and reduces Q80 aggregates in vitro. Inhibition of QPCT also reduces aggregate formation in in vivo models of Huntington's disease. SEN 177 potently inhibits QPCT-like protein (IC50 = 13 nM) and disrupts binding of SIRP-α to CD47. The compound increases antibody-dependent cellular phagocytosis and cytotoxicity in cancer cell lines.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 6 '-Fluoro-2-[4-(4-methyl-4 H-1,2,4-triazol-3-yl)-1-piperidinyl]-3,3 '-bipyridine
CAS 2117405-13-5
Quantity 10 mg
Target Other Transferase Inhibitors
Molecular Formula C18H19FN6
Purity 0.98
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