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STEMCELL Technologies Tamoxifen

Product Code. 17160102
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Quantity:
500 mg
5 g
10 g
Unit Size:
10g
500mg
5g
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Product Code. Quantity unitSize
17160102 10 g 10g
17140102 500 mg 500mg
17150102 5 g 5g
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Product Code. 17160102 Supplier STEMCELL Technologies Supplier No. 72666

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Beschreibung

Estrogen signaling pathway modulator; Modulates selective estrogen receptor and estrogen-related receptor

  • Tamoxifen is a selective estrogen receptor modulator (SERM), with tissue-specific antagonistic or agonistic effects
  • Receptor activation leads to the formation of homo- and hetero-dimers, which in turn interact with accessory proteins to regulate gene transcription
  • Tamoxifen is commonly used to activate Cre-ER in transgenic conditional models
  • Used in transgenic models to induce Cre-mediated recombination in conjunction with Cre-ER, a fusion protein consisting of Cre recombinase and a mutant form of the estrogen receptor hormone-binding domain that specifically binds tamoxifen but not estrogen (Feil et al.; Zhang et al.)
  • Inhibits growth in the human breast cancer cell line, MCF-7 (Katzenellenbogen et al.)
  • Antagonist of estrogen receptor action in breast tissue and breast cancer cells (Abe et al.; Horwitz et al.)

Spezifikation

CAS 10540-29-1
Synonym trans-Tamoxifen
Quantity 10 g
Molecular Formula C26H29NO
Purity ≥95%
Name des Produkts
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