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tert-Butyl carbazate, 98+%
Description
tert-Butyl carbazate is used in a palladium-catalyzed cross-coupling with vinyl halides to prepare N-Boc-N-alkenylhydrazines. It is utilized in solid phase peptide synthesis and in the optical purity determination of alfa-amino aldehyde. It reacts with aldehydes to get hydrazones, which finds application as an intermediate in the synthesis of HIV-1 protease inhibitors. In addition to this, it is used as a starting material for the preparation of BOC-azide, sulfonic and carboxylic hydrazides.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
tert-Butyl carbazate is used in a palladium-catalyzed cross-coupling with vinyl halides to prepare N-Boc-N-alkenylhydrazines. It is utilized in solid phase peptide synthesis and in the optical purity determination of alfa-amino aldehyde. It reacts with aldehydes to get hydrazones, which finds application as an intermediate in the synthesis of HIV-1 protease inhibitors. In addition to this, it is used as a starting material for the preparation of BOC-azide, sulfonic and carboxylic hydrazides.
Solubility
Soluble in ethanol and methanol.
Notes
Store in a cool place. Incompatible with strong oxidizing agents and strong bases.
Specifications
Specifications
| Melting Point | 37°C to 41°C |
| Boiling Point | 63°C to 65°C (0.1 mmHg) |
| Flash Point | 91°C (195°F) |
| Quantity | 25 g |
| UN Number | UN1325 |
| Beilstein | 1756967 |
| Sensitivity | Moisture sensitive |
| Solubility Information | Soluble in ethanol and methanol. |
| Formula Weight | 132.16 |
| Percent Purity | ≥98% |
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Safety and Handling
- tert-Butyl carbazate
- Danger
- Acute toxicity Category 3
- Serious eye damage/eye irritation Category 2
- Flammable solid Category 2
- Skin corrosion/irritation Category 2
- Specific target organ toxicity Category 3
- H228-Flammable solid.
- H301-Toxic if swallowed.
- H311-Toxic in contact with skin.
- H315-Causes skin irritation.
- H319-Causes serious eye irritation.
- H335-May cause respiratory irritation.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
- P302+P352-IF ON SKIN: Wash with plenty of water/soap.
- P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P312-Call a POISON CENTER/doctor/if you feel unwell.
- MIXTURE LIST-Contains : tert-Butyl carbazate
RUO – Research Use Only
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