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  5. STEMCELL Technologies TWS119

STEMCELL Technologies TWS119

Product Code. p-7217470
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17170232 1 mg 1mg
17180232 10 mg 10mg
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Product Code. 17170232 Supplier STEMCELL Technologies Supplier No. 73512

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Description

WNT pathway activator; Inhibits GSK3β

  • TWS119 is a potent disubstituted pyrrolopyrimidine inhibitor of glycogen synthase kinase 3 beta (GSK3β) with an IC50 of 30 nM and Kd of 126 nM (Ding et al.) GSK3 is a serine/threonine kinase that is a key inhibitor of the WNT pathway; therefore TWS119 functions as a WNT pathway activator
  • Maintains the bi-potent, quiescent state in hepatic stellate cells of Wistar rats (Kordes et al.)
  • Induces differentiation of mouse embryonal carcinoma and embryonic stem cells to neurons (Ding et al.)
  • Induces production of T memory stem cell-like (T-SCM) cells from mouse or human CD8+ T cells with evidence of increased persistence, proliferation, and anti-tumor activity after adoptive transfer of mouse-derived T-SCM (Forget et al.; Gattinoni et al.)
  • Inhibits cell proliferation and induces apoptosis in human alveolar rhabdomyosarcoma cells (Zeng et al.)

Specifications

CAS 601514-19-6
Synonym GSK 3B Inhibitor XII
Quantity 1 mg
Molecular Formula C18H14N4O2
Purity ≥90%
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