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Tocris Bioscience™ xStAx-VHLL
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Product Code. 18767016
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Quantity:
100 μg
Unit Size:
100µg
This item is not returnable. View return policy

Product Code. 18767016

Brand: Tocris Bioscience™ 7298/100U

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This item is not returnable. View return policy

Description

Selective peptide-based β-catenin Degrader (PROTAC™)

xStAx-VHLL is a selective peptide-based β-catenin Degrader (PROTAC™). Comprises a β-catenin-targeted stapled peptide, xStAx, linked to a VHL-binding peptide. Reduces β-catenin levels in HEK293T cells and colorectal cancer cell lines. Selectively degrades β-catenin over other Wnt signaling pathway components. Inhibits tumor growth in APCmin/+ mice, with constitutively active Wnt signaling, and reduces survival of patient-derived colorectal cancer cell organoids. PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.
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Specifications

Purity 95%
Content And Storage Store at -20°C
Quantity 100 μg
Target Entry Active Degraders
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