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  5. Tocris Bioscience™ Y-27632 dihydrochloride

Tocris Bioscience™ Y-27632 dihydrochloride
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Product Code. 30001217
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Product Code. Quantity unitSize
30001217 1 mg 1mg
18084362 10 mg 10mg
18044982 50 mg 50mg
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Product Code. 30001217

Brand: Tocris Bioscience™ 1254/1

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Description

Selective p160ROCK inhibitor

Y-27632 dihydrochloride is a selective ROCK inhibitor (Ki values are 0.14-0.22, 0.3, 25, 26 and > 250 μM for ROCK1 (p160 ROCK), ROCK2, PKA, PKC and MLCK respectively). Also inhibits PRK2 (IC50 = 600 nM). Increases survival rate of human embryonic stem (hES) cells and iPSC undergoing cryopreservation. Used in combination with CHIR99021, RepSox, Forskolin, SP 600125, Go 6983 and VPA to reprogram fibroblasts to mature neurons. Also optimizes naive human pluripotent stem cell growth and viability following naive cell derivation from primed ESCs and iPSCs using naive human stem cell medium (NHSM). Used as component of growth media for urothelial organoids. Cell-permeable, orally bioavailable and active in vivo. Y-27632 synthesized to cGMP guidelines also available.

For more information about how Y-27632 dihydrochloride may be used, see our protocols: Transdifferentiating Fibroblasts into Neurons, Converting Fibroblasts into Cardiomyocytes (9C Cocktail), Accelerated Induction of Cortical Neurons from hiPSCs, Human iPSC-derived Myoblasts .

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Chemical Identifiers

CAS 129830-38-2
Molecular Formula C14H23Cl2N3O

Specifications

Quantity 1 mg
Formula Weight 320.26
Purity >98%
Molecular Weight (g/mol) 320.258
Chemical Name or Material Y-27632 dihydrochloride
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