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  5. Tocris Bioscience™ ZLN 024 hydrochloride

Tocris Bioscience™ ZLN 024 hydrochloride

Product Code. 18714929
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50 mg
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18714929 10 mg 10mg
18776209 50 mg 50mg
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Product Code. 18714929 Supplier Tocris Bioscience™ Supplier No. 5285/10

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Description

Allosteric AMPK activator

ZLN 024 hydrochloride is an allosteric AMP-activated protein kinase (AMPK) activator; allosterically stimulates active AMPK heterotrimers, increasing the activity of α1β1γ1 by 1.5-fold and α2β1γ1 by 1.7-fold (EC50 values are 0.42 and 0.95 μM, respectively). Inhibits dephosphorylation of AMPK Thr-172 by PP2Cα. Stimulates glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio. Also decreases fatty acid synthesis and glucose output in primary hepatocytes. Improves glucose tolerance and decreases cholesterol content in db/db mice.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]pyrimidine hydrochloride
Quantity 10 mg
Target AMPK Activators
Molecular Formula C13H13BrN2OS.HCl
Formula Weight 361.69
Purity >99%
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