CAS RN 1195765-45-7

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MedChemExpress Dabrafenib (GSK2118436A) is an ATP-competitive inhibitor of Raf with IC50s of 5 nM and 0.6 nM for C-Raf and B-RafV600E, respectively.

Molecular Weight (g/mol)	519.56
Color	Off-White
Physical Form	Solid
Chemical Name or Material	Dabrafenib
Grade	Research
SMILES	CC(C)(C)C1=NC(C2=C(F)C(NS(C3=C(F)C=CC=C3F)(=O)=O)=CC=C2)=C(C4=CC=NC(N)=N4)S1
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	95.0%
CAS	1195765-45-7
Solubility Information	DMSO : ≥ 33 mg/mL (63.52 mM)
Synonym	GSK2118436A GSK2118436
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₃H₂₀F₃N₅O₂S₂
Formula Weight	519.56

MEK/ERK pathway inhibitor; Inhibits B-RAF V600E