CAS RN 1363281-27-9

IUPAC Name: —

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Selective mGlu5 positive allosteric modulator; brain penetrant and orally bioavailable

Target	Group I mGluR Modulators
CAS	1363281-27-9
Purity	>98%
Chemical Name or Material	[6,7-Dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](fluorophenyl)methanone
Recommended Storage	Store at 4°C
Synonym	JNJ 46778212
Molecular Formula	C₂₀H₁₇FN₂O₃
Formula Weight	352.36

MedChemExpress JNJ-46778212 (VU 0409551) is an mGlu5 positive allosteric modulator with an EC50 of 260 nM.

Molecular Weight (g/mol)	352.36
Color	Yellow
Physical Form	Solid
Chemical Name or Material	JNJ-46778212
Grade	Research
SMILES	O=C(N1CCC2=C(OC(COC3=CC=CC=C3)=N2)C1)C4=CC=C(F)C=C4
For Use With (Application)	Neuroscience-Neurodegeneration
Percent Purity	99.46%
CAS	1363281-27-9
Solubility Information	DMSO : ≥ 125 mg/mL (354.75 mM)
Synonym	VU 0409551
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₀H₁₇FN₂O₃
Formula Weight	352.36

Selective mGlu5 positive allosteric modulator; brain penetrant and orally bioavailable

Selective mGlu5 positive allosteric modulator; brain penetrant and orally bioavailable