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CAS RN 1439399-58-2

CAS RN 1439399-58-2

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1 – 3 of 3 results
1

CB-839, TRC

CAS: 1439399-58-2 Molecular Formula: C26H24F3N7O3S Molecular Weight (g/mol): 571.57 Synonym: N-[5-[4-[6-[[2-[3-(Trifluoromethoxy)phenyl]acetyl]amino]-3-pyridazinyl]butyl]-1,3,4-thiadiazol-2-yl]-2-pyridineacetamide IUPAC Name: N-[6-[4-[5-[(2-pyridin-2-ylacetyl)amino]-1,3,4-thiadiazol-2-yl]butyl]pyridazin-3-yl]-2-[3-(trifluoromethoxy)phenyl]acetamide SMILES: FC(F)(F)Oc1cccc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)s3)nn2)c1

CAS 1439399-58-2
Molecular Weight (g/mol) 571.57
SMILES FC(F)(F)Oc1cccc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)s3)nn2)c1
Synonym N-[5-[4-[6-[[2-[3-(Trifluoromethoxy)phenyl]acetyl]amino]-3-pyridazinyl]butyl]-1,3,4-thiadiazol-2-yl]-2-pyridineacetamide
IUPAC Name N-[6-[4-[5-[(2-pyridin-2-ylacetyl)amino]-1,3,4-thiadiazol-2-yl]butyl]pyridazin-3-yl]-2-[3-(trifluoromethoxy)phenyl]acetamide
Molecular Formula C26H24F3N7O3S
2

Tocris Bioscience™ CB 839
GREENER_CHOICE

Potent glutaminase GLS1 inhibitor

Target Glutaminase Inhibitors
CAS 1439399-58-2
Purity 0.98
Chemical Name or Material N-[5-[4-[6-[[2-[3-(Trifluoromethoxy)phenyl]acetyl]amino]-3-pyridazinyl]butyl]-1,3,4-thiadiazol-2-yl]-2-pyridineacetamide
Recommended Storage Store at -20°C
Molecular Formula C26H24F3N7O3S
3

Telaglenastat, MedChemExpress

MedChemExpress Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inudces autophagy and has antitumor activity.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 571.57
Color Light Brown
Physical Form Solid
Chemical Name or Material Telaglenastat
Grade Research
SMILES O=C(NC1=NN=C(CCCCC2=NN=C(NC(CC3=CC=CC(OC(F)(F)F)=C3)=O)C=C2)S1)CC4=NC=CC=C4
For Use With (Application) Cancer-programmed cell death
Percent Purity 98.0%
CAS 1439399-58-2
Solubility Information DMSO : 6.29 mg/mL (11.00 mM; Need ultrasonic)
Synonym CB-839
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C26H24F3N7O3S
Formula Weight 571.57