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Telaglenastat, MedChemExpress

Produktkod. 16491277
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Produktkod. 16491277 Leverantör Medchem Express Leverantörsnummer HY12248
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Estimated Shipment: 28-10-2026
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Beskrivning

MedChemExpress Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inudces autophagy and has antitumor activity.

Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inudces autophagy and has antitumor activity.

Specifikationer

Chemical Name or Material Telaglenastat
CAS 1439399-58-2
Color Light Brown
Purity Grade Notes Research
Molecular Formula C26H24F3N7O3S
Quantity 50 mg
Synonym CB-839
Solubility Information DMSO : 6.29 mg/mL (11.00 mM; Need ultrasonic)
SMILES O=C(NC1=NN=C(CCCCC2=NN=C(NC(CC3=CC=CC(OC(F)(F)F)=C3)=O)C=C2)S1)CC4=NC=CC=C4
Molecular Weight (g/mol) 571.57
Formula Weight 571.57
Percent Purity 98.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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