CAS RN 1949837-12-0

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Tocris Bioscience™ ARV 771

Potent BET bromodomain PROTAC™; also degrades BRD-tagged chimeric antigen receptors (CAR) in T cells

Pricing and Availability

MedChemExpress ARV-771 is a potent BET PROTAC based on E3 ligase von Hippel-Lindau with Kds of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	986.64
Color	White
Physical Form	Solid
Chemical Name or Material	ARV-771
Grade	Research
SMILES	CC(C(C(C1=CC=C(Cl)C=C1)=N[C@@H](CC(NCCOCCCOCC(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C2)[C@@H]2C(N[C@H](C3=CC=C(C(SC=N4)=C4C)C=C3)C)=O)=O)=O)=O)C5=NN=C(C)N65)=C6S7)=C7C
For Use With (Application)	Cancer-programmed cell death
Percent Purity	96.75%
CAS	1949837-12-0
Solubility Information	DMSO : ≥ 50 mg/mL (50.68 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₄₉H₆₀ClN₉O₇S₂
Formula Weight	986.64

CAS RN 1949837-12-0

CAS RN 1949837-12-0

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Tocris Bioscience™ ARV 771 Greener Choice ProductThis product offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”Learn More About the Greener Choice Program

Tocris Bioscience™ ARV 771