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PZ-2891, MedChemExpress

Product Code. 16475876
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Product Code. 16475876

Brand: Medchem Express HY124634

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Description

MedChemExpress PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 40.2 nM, 0.7 nM and 1.3 nM, respectively.

PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 40.2 nM, 0.7 nM and 1.3 nM, respectively.

Specifications

Chemical Name or Material PZ-2891
CAS 2170608-82-7
Color Off-White
Purity Grade Notes Research
Molecular Formula C20H23N5O
Quantity 100 mg
Solubility Information DMSO : 75 mg/mL (214.64 mM; Need ultrasonic)
SMILES N#CC1=NN=C(N2CCN(C(CC3=CC=C(C(C)C)C=C3)=O)CC2)C=C1
Molecular Weight (g/mol) 349.43
Formula Weight 349.43
Percent Purity 98.4%
Grade Research
Physical Form Solid
For Use With (Application) Neuroscience-Neuromodulation
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Research purposes only

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