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  8. AX-024 hydrochloride, MedChemExpress

AX-024 hydrochloride, MedChemExpress

Product Code. 16416827
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Product Code. 16416827

Brand: Medchem Express HY107390A

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Description

MedChemExpress AX-024 hydrochloride is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ∼1 nM. AX-024 hydrochloride modulates cell signaling by targeting SH3 domains. AX-024 hydrochloride has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.

AX-024 hydrochloride is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ∼1 nM. AX-024 hydrochloride modulates cell signaling by targeting SH3 domains. AX-024 hydrochloride has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.

Specifications

Chemical Name or Material AX-024 hydrochloride
CAS 1704801-24-0
Color White
Purity Grade Notes Research
Molecular Formula C21H23ClFNO2
Quantity 5 mg
Solubility Information DMSO : 33 mg/mL (87.80 mM; Need ultrasonic and warming) ∣H2O : 16.67 mg/mL (44.35 mM; Need ultrasonic)
SMILES COC1=CC=C(OC2)C(C(C3=CC=C(F)C=C3)=C2CN4CCCC4)=C1.[H]Cl
Molecular Weight (g/mol) 375.86
Formula Weight 375.86
Percent Purity 99.12%
Grade Research
Physical Form Solid
For Use With (Application) COVID-19-immunoregulation
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Research purposes only

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