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  7. 4-Methylumbelliferyl sulfate potassium salt, 98%

4-Methylumbelliferyl sulfate potassium salt, 98%

Product Code. 15487409
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5 g
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Product Code. 15487409 Supplier Thermo Scientific Alfa Aesar Supplier No. J66160.03
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Description

Substrate for sulfatase | CAS: 15220-11-8 | C10H7KO6S | 294.318 g/mol

4-Methylumbelliferyl sulfate potassium salt is a fluorometric substrate for the determination of sulfatase. This substrate has been used in the discovery of tyrosine sulfotransferase inhibitors, particularly in P-selectin glycoprotein ligand-1 binding. This compound is virtually non-fluorescent until cleavage by sulfatase enzymes, then emits blue fluorescence (450 nm) with excitation at 360 nm. Use of this compound in high-throughput fluorescence based screening led to the discovery of several potent beta-arylsulfotransferase IV (beta-AST-IV) inhibitors.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
4-Methylumbelliferyl sulfate potassium salt is a fluorometric substrate for the determination of sulfatase. This substrate has been used in the discovery of tyrosine sulfotransferase inhibitors, particularly in P-selectin glycoprotein ligand-1 binding. This compound is virtually non-fluorescent until cleavage by sulfatase enzymes, then emits blue fluorescence (450 nm) with excitation at 360 nm. Use of this compound in high-throughput fluorescence based screening led to the discovery of several potent beta-arylsulfotransferase IV (beta-AST-IV) inhibitors.

Solubility
Soluble in water at 5mg/ml

Notes
Excitation wavelength, 334 nm; emission wavelength, 370nm (pH 10.4). Reaction product: excitiation wavelength, 360nm; emission wavelength, 449nm
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 15220-11-8
Molecular Formula C10H7KO6S
Molecular Weight (g/mol) 294.318
MDL Number MFCD00016970
InChI Key CSOCSPXOODWGLJ-UHFFFAOYSA-M
Synonym 4-methylumbelliferyl sulfate potassium salt, 2h-1-benzopyran-2-one, 4-methyl-7-sulfooxy-, potassium salt, 4-methylumbelliferyl sulfate, potassium salt, 2h-1-benzopyran-2-one, 4-methyl-7-sulfooxy-, potassium salt 1:1, potassium 4-methyl-2-oxo-2h-chromen-7-yl sulfate, potassium 4-methyl-2-oxochromen-7-yl sulfate, c10h7o6s.k, potassium 4-methyl-2-oxo-2h-1-benzopyran-7-yl sulphate, potassium 4-methylumbelliferyl sulfate
PubChem CID 5044226
IUPAC Name potassium;(4-methyl-2-oxochromen-7-yl) sulfate
SMILES CC1=CC(=O)OC2=C1C=CC(=C2)OS(=O)(=O)[O-].[K+]

Specifications

Color White to Yellow
Quantity 1 g
Beilstein 3803203
Solubility Information Soluble in water at 5mg/ml
Formula Weight 294.32
Percent Purity 98%
Physical Form Powder
Chemical Name or Material 4-Methylumbelliferyl sulfate potassium salt

RUO – Research Use Only

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